High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 μm
Year: 2015
Type: article
Abstract: m spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacoustic/intravascular ultrasound (IVPA/IVUS) imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A lipid-mimicking phantom and atherosclerotic rabbit abdominal aorta were imaged at 1 frame per second, which is two orders of magnitude faster than previously reported in IVPA imaging with the same wavelength. Clear photoacoustic signals by the absorption of lipid rich deposition demonstrated the ability of the system for high speed vulnerable atherosclerotic plaques detection.
Source: Applied Physics Letters
DOI: 10.1063/1.4929584
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Funders: Foundation for the National Institutes of Health, National Research Foundation, National Research Foundation of Korea, National Institutes of Health, National Heart, Lung, and Blood Institute, National Eye Institute, National Institute of Biomedical Imaging and Bioengineering, Air Force Office of Scientific Research
Awards: G1523888516, G2427206007, Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration, G3700431609, Modeling the Pediatric Upper Airway using A-OCT and Computational Fluid Dynamics, G729259970, G7519571385, Combined OCT/US/PAT system for intravascular Imaging, A Laser Microbeam Biotechnology Resource, Phase resolved ARF optical coherence elastography for intravascular imaging
OpenAlex ID: W1933457697