Work

Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome

Year: 2015

Type: article

Source: Nature Neuroscience

DOI: 10.1038/nn.4072

Authors: Jonathan Witton, Ragunathan Padmashri, Larissa E Zinyuk, Victor I Popov, Igor Kraev, Samantha J Line, Thomas P Jensen, Angelo Tedoldi, Damian M Cummings, Victor L J Tybulewicz, Elizabeth M C Fisher, David M Bannerman, Andrew D Randall, Jonathan T Brown, Frances A Edwards, Dmitri A Rusakov, Michael G Stewart, Matt W Jones

Institutions: University of Bristol, UCL Queen Square Institute of Neurology, University College London, Russian Academy of Sciences, The Open University, Institute of Cell Biophysics, University of Oxford, National Institute for Medical Research

Language: English

Topic: Down syndrome and intellectual disability research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, Alzheimer's Society, Medical Research Council, Biotechnology and Biological Sciences Research Council

Awards: G1155769795, The London Down Syndrome Consortium (LonDownS): An integrated system to study the development and therapeutic amelioration of cognition and dementia., High resolution 3-D reconstructions from brain tissue via Field Emission scanning electron microscopy in back scattered electron (BSE) imaging mode, Neurotoxicity of human serum amyloid P component, Targeted drug delivery to neurons and glia using light- and field-sensitive microcapsules, Genetic dissections of hippocampal function., The Role of Multi-innervated Dendritic Spines in Memory Formation in Ageing, Neural coding with the tripartite synapse., A genetic dissection of brain and heart phenotypes in the Tc1 transchromosomic mouse model of Down syndrome, Understanding Down syndrome phenotypes through innovative mouse genetics.

OpenAlex ID: W1960456385

FWCI: 7.565

Cites: 47

Cited by: 43

Related to: 10