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Recent Advances and Future Challenges in Glycan Microarray Technology

Year: 2011

Type: book-chapter

Abstract: Glycan microarrays, carrying hundreds of different sugars on chip surfaces, have become a standard tool for the study of interactions of biomolecules with carbohydrates. The chip-based format offers important advantages, including the ability to screen in parallel several thousand binding events on a single slide, the minimal amount of sample required for one experiment, and the multivalent display of sugars on the chip that mimics the presentation of carbohydrates in nature. This chapter presents recent advances and future challenges in glycan microarray technology. We describe different immobilization and detection methods as well as applications in glycomics, drug discovery, and biomedicine.

Source: Methods in molecular biology

DOI: 10.1007/978-1-61779-373-8_1

Authors: José L. de Paz, Peter H. Seeberger

Institutions: Consejo Superior de Investigaciones Científicas, Centro de Investigaciones Científicas Isla de la Cartuja, Instituto de Investigaciones Químicas, Max Planck Institute of Colloids and Interfaces, Freie Universität Berlin

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Max-Planck-Gesellschaft, Ministerio de Ciencia e Innovación

OpenAlex ID: W1962070539

FWCI: 5.269

Cites: 64

Cited by: 34

Related to: 10