Work

Dependence of Neutrophil Activation on Cell Density and Adhesion

Year: 1998

Type: article

Abstract: Upon an increasing cell density human neutrophils develop more cell-to-cell contacts in conjunction with an increase in the pHi. These changes are accompanied by decreased superoxide formation after adherence, and a decrease in the total amount of 5-lipoxygenase products after various stimuli. Among the various arachidonate metabolites, leukotriene formation remained almost constant but the yield in 5-HETE decreased. This drop in could account for the decrease in total 5-lipoxygenase products observed when the cell density increased. We conclude that cellular signalling can be affected by an increase of cell-cell interactions. Whether the increase in cellular pH is a cause or consequence of such contact inhibition has yet be answered.

Source: Cell Communication & Adhesion

DOI: 10.3109/15419069809005596

Authors: Galina F. Sud'ina, Svetlana I. Galkina, Leonid B. Margolis, Volker Ullrich

Institutions: Lomonosov Moscow State University, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of Konstanz

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Russian Foundation for Basic Research