Year: 1990
Type: article
Abstract: The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch-clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between -50 and +30 mV. The forskolin-induced increase of INa was mimicked by 1,9-dideoxyforskolin (0.5 microM) but not by isoprenaline (2 microM). These results suggest that forskolin can modulate INa through a mechanism that does not involve the production of cyclic AMP.
Source: Experimental Physiology
Authors: R Bonvallet, F Lemtiri-Chlieh, O Rougier
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1964768875