Work

Long noncoding RNAs in biology and hematopoiesis

Year: 2013

Type: article

Abstract: Genome and transcriptome sequencing have revealed a rich assortment of noncoding RNAs in eukaryote cells, including long noncoding RNAs (lncRNAs), which regulate gene expression independent of protein coding potential. LncRNAs modulate protein coding gene expression in many cell types by regulating multiple processes, including epigenetic control of transcription, mRNA stability, and protein localization. Although little is known about lncRNAs in hematopoiesis, they are likely to exert widespread roles in this process.

Source: Blood

DOI: 10.1182/blood-2013-03-456111

Authors: Vikram R. Paralkar, Mitchell J. Weiss

Institutions: University of Pennsylvania, Children's Hospital of Philadelphia

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Society of Hematology, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases