Atherosclerotic Plaque Targeting Mechanism of Long-Circulating Nanoparticles Established by Multimodal Imaging
Year: 2015
Type: article
Abstract: Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis.
Source: ACS Nano
DOI: 10.1021/nn506750r
Authors: Mark E. Lobatto, Claudia Calcagno, Antoine Millon, Max L. Senders, Francois Fay, Philip M. Robson, Sarayu Ramachandran, Tina Binderup, Maarten P.M. Paridaans, Steven Sensarn, Stephan Rogalla, Ronald E. Gordon, Luis Cardoso, Gert Storm, Josbert M. Metselaar, Christopher H. Contag, Erik S. G. Stroes, Zahi A. Fayad, Willem J.M. Mulder
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Funders: European Commission, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, U.S. Public Health Service, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources
Awards: G140661078, G1777385710, Theranostic HDL nanoparticles for inflammatory macrophages in atherosclerosis, Anti-inflammatory nanoparticle formulations to treat atherosclerosis, G416743114, PET/MRI to study nanotherapy in atherosclerosis, Mechanical Function of Trabecular Bone: Bone Loss Assessment Beyond BMD, Advanced Microscopy Shared Resource Facility, G6632036768
OpenAlex ID: W1965211476