Studies of Gastric Pepsin. Ii. Secretion of Pepsin in Cases of Duodenal Ulcer and Pseudo-ulcer
Year: 1933
Type: article
Study design: Observational Study
Abstract: Few articles on concentration of pepsin in the gastric juice of patients with disease of the stomach and duodenum are to be found in recent liter- ature, and the results reported by different observers are not always in accord.We shall consider here only the concentration of pepsin in the gastric juice of persons suffering with the syndrome of peptic ulcer.Wilcox (5), in 1908, reported that the concentration of pepsin in the gastric juice of persons with peptic ulcer and hyperacidity was usually higher, and never lower, than normal.Boas (1), in 1925, and Hirsch- Mamroth and Rindfleisch (3) likewise found that the concentration of pepsin was elevated in the presence of ulcer, provided blood was not present in the sample examined, but they quoted other workers who at times failed to find any increase.Polland and Bloomfield (4) reported that the range of concentration of pepsin was the same in patients with ulcer as in normal persons.We have estimated the concentration of pepsin by a modification of the
DOI: 10.1172/jci100518
Institution: Mayo Clinic
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1965665366