COMPARISON OF INTRATHECAL BUPIVACAINE (17.5mg) WITH PRESERVATIVE FREE MIDAZOLAM (1mg) VERSUS INTRATHECAL BUPIVACAINE (17.5mg) FOR POSTOPERATIVE PAIN RELIEF IN LOWER LIMB SURGERIES.
Year: 2013
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: Spinal anaesthesia is a common anaesthetic technique for lower limb surgery. Many adjutants have been tried to prolong the duration of analgesia provided by local anaesthetics when administered intrathecally. Midazolam has been shown to prolong the duration of analgesia when used as an adjuvant, providing the added advantages of mild sedation and amnesia, while being devoid of neurotoxicity, and the adverse effects of opioids. This study was designed to evaluate the effect of 1 mg preservative-free intrathecal midazolam added to spinal bupivacaine during postoperative analgesia, and the incidence of adverse effects, if any, in patients undergoing knee arthroscopies. Method: 60 consenting American Society of Anesthesiologists (ASA) physical status I or II patients of either gender (men = 48, women = 12), aged between 20-60 years, were randomly allocated to two groups (30 each). Group B received 0.5% hyperbaric bupivacaine with saline intrathecally, and Group BM received 0.5% hyperbaric bupivacaine with preservative-free midazolam 1 mg intrathecally. Peak sensory level, total duration of analgesia, duration of motor blockade, pain score using the Visual Analogue Scale, and sedation score using the Observer Assessment Score of Sedation were assessed, along with vital parameters, namely heart rate and systolic, diastolic and mean blood pressure. Results: The total duration of analgesia observed was significantly higher in Group BM (336.2
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1968190098