Work

An efficient approach to homocoupling of terminal alkynes: Solvent-free synthesis of 1,3-diynes using catalyticCu(ii) and base

Year: 2009

Type: article

Abstract: We report an environmentally friendly, efficient method for transforming terminal acetylenes into 1,3-diynes based on catalytic amounts of a Cu(II) salt and base under solvent-free conditions. The developed process conforms to the principles of ‘green’ chemistry and addresses the shortage of such methods for the synthesis of 1,3-diynes. The reaction is quite general and results in good yields. Interestingly, the system also allows the synthesis of unsymmetric 1,3-diynes by cross-coupling of two different terminal alkynes. Finally, the catalyst can also be recycled.

Source: Green Chemistry

DOI: 10.1039/b917448f

Authors: Dong Wang, Jihui Li, Na Li, Tingting Gao, Sihua Hou, Baohua Chen

Institutions: State Key Laboratory of Applied Organic Chemistry, Lanzhou University

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Responsible consumption and production

Open Access status: green

Funder: National Natural Science Foundation of China