Sunitinib induced nephrotic syndrome and thrombotic microangiopathy
Year: 2013
Type: article
Study design: Case Report
Abstract: Sunitinib is an oral, multitargeted receptor tyrosine kinase inhibitor of targets such as vascular endothelial growth factor and platelet derived growth factor receptor. It is used for the treatment of metastatic renal cell carcinoma (RCC). Use of sunitinib has been associated with renal dysfunction and nephrotic syndrome. However, simultaneous occurrence of nephrotic syndrome and renal dysfunction in a patient treated with sunitinib is rare. We report a case of metastatic RCC treated with sunitinib for 22 months who presented with nephrotic syndrome and renal dysfunction. Renal biopsy was diagnostic of thrombotic microangiopathy with diffuse effacement of podocytic foot process.
Source: Indian Journal of Nephrology
Authors: M Vankalakunti, PK Jha, V Siddini, R Bonu, GK Prakash, K Babu, HS Ballal
Institution: Manipal Hospital
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1968784486