Work

Parasitic Infections: A Role for C-Type Lectins Receptors

Year: 2013

Type: review

Abstract: Antigen-presenting cells (APCs) sense the microenvironment through several types of receptors that recognize pathogen-associated molecular patterns. In particular, C-type lectins receptors (CLRs), which are expressed by distinct subsets of dendritic cells (DCs) and macrophages (MØs), recognize and internalize specific carbohydrate antigens in a Ca(2+)-dependent manner. The targeting of these receptors is becoming an efficient strategy for parasite recognition. However, relatively little is known about how CLRs are involved in both pathogen recognition and the internalization of parasites. The role of CLRs in parasite infections is an area of considerable interest because this research will impact our understanding of the initiation of innate immune responses, which influences the outcome of specific immune responses. This paper attempts to summarize our understanding of the effects of parasites' interactions with CLRs.

Source: BioMed Research International

DOI: 10.1155/2013/456352

Authors: Alicia Vázquez-Mendoza, Julio César Carrero, Miriam Rodriguez-Sosa

Institutions: Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,680

Funders: Consejo Nacional de Ciencia y Tecnología, Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México