Work

Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study

Year: 2013

Type: article

Abstract: The aim of this study was to investigate the role of the XRCC1 Arg399Gln polymorphism in the susceptibility of a Kashmiri population to colorectal cancer (CRC). We investigated the genotype distribution of the XRCC1 gene in 130 CRC cases in comparison with that of 150 healthy subjects. There was no direct significant association between the XRCC1 genotypes and CRC; however, the Arg/Gln genotype was associated with an elevated risk of CRC (OR>1.47) and the Gln/Gln variant genotype was associated with an increased risk of CRC in various clinicopathological parameters. This study suggests that the XRCC1 polymorphism is associated with an increased risk of CRC.

Source: Oncology Letters

DOI: 10.3892/ol.2013.1104

Authors: SANIYA NISSAR, TUFAIL AHMAD LONE, MUJEEB ZAFAR BANDAY, ROOHI RASOOL, NISSAR A. CHOWDRI, FAZL Q. PARRAY, SAFIYA ABDULLAH, AGA SYED SAMEER

Institutions: Sher-i-Kashmir Institute of Medical Sciences, University of Kashmir

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1969880267

FWCI: 4.224

Cites: 39

Cited by: 34

Related to: 10