A lineage of hepatitis E virus within genotype IV, associated with severe forms of hepatitis
Year: 2005
Type: article
Abstract: We found a lineage of hepatitis E virus (HEV) within genotype IV, members of which were JSF-Tot03C, JSN-Sap-FH02C, JYN-Sap 01C, HE-JK4, JYN-Nii 02L, HE-JF3, HE-JA1, HE-JI4 from humans and swJ13-1 from swine, all from Japan. Interestingly, of 9 patients infected with the HEV of this lineage, 3 were with fulminant hepatitis, and another 3 were with considerably prolonged prothrombin time (17%, 40% and 44%). In addition, at least 6 patients showed bilirubin levels greater than 10 mg/dl. Although host factors (pregnancy for example) may contribute much to clinical phenotypes of HEV infections, our present results suggest that a viral factor may also play an important role therein.
Source: Kanzo
DOI: 10.2957/kanzo.46.389
Authors: K Takahashi, K Okada, JH Kang, Y Karino, T Ichida, H Matsuda, S Ohnishi, J Toyota, S Yamagiwa, H Maekubo, N Abe, S Mishiro
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1970660668