Hormonal therapy in cancer of the breast, XIII. The effect of 9α-fluoro-17α-methyl-Δ4-androsten-3-one-11β,17β-diol (fluoxymesterone) therapy on clinical course and hormonal excretion
Year: 1958
Type: article
Abstract: HE ANDROGENIC steroids most effective in T the treatment of metastatic breast cancer have all been potent androgens.T o date, the less potent androgens have been less effective.3~4Hence, when an androgen more potent than testosterone or methyltestosterone became available it was thought important to test it immediately for effectiveness against advanced breast cancer.It is of great interest that although the introduction of an 11shydroxyl group in testosterone reduces its androgenic potency, when this is coupled with the introduction of a 9a-fluoro group of methyltestosterone, it produces an increase in oral androgenic potency.
Source: Cancer
Institutions: Tulane University, Ochsner Medical Center
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1970758387