Work

Detection of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice Using USPIO-Enhanced Magnetic Resonance Imaging

Year: 2011

Type: article

Abstract: Atherosclerosis is a cardiovascular disease with an accompanying inflammatory response, in which macrophages play an important role.Magnetic resonance imaging (MRI) using ultrasmall superparamagnetic iron oxide (USPIO) particles as a contrast agent has been used in several inflammatory diseases.The USPIO taken up by macrophages reduces the signal intensity on MRI images.Using USPIO-enhanced MRI at 7 T, we could detect atherosclerotic lesions in the brachiocephalic artery of apolipoprotein E (ApoE) knockout (KO) mouse fed a high-fat diet as a model of atherosclerosis.

Source: Journal of Nippon Medical School

DOI: 10.1272/jnms.78.136

Authors: Mika Murabayashi, Taku Sugita, Keiko Hirakawa, Hideto Kuribayashi, Ikuo Mori, Kazuki Kubo, Takashi Horiguchi, Masayuki Ueda, Yasuo Katayama, Youkichi Ohno

Institutions: Takeda (Japan), Nippon Medical School

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1971285508

FWCI:

Cites:

Cited by: 1

Related to: 10