Year: 1970
Type: article
Study design: Observational Study
Abstract: The characteristic stigmata of Down's syndrome (mongolism, trisomy 21) are rarely obscured by racial features (Emanuel, Huang, and Yeh, 1968).However, occasional patients, particularly infants, from any ethnic group may be difficult to diagnose clinically.In these equivocal situations and whenever confirmatory tests are indicated, a dermatogly- phic analysis of finger, hand, and foot prints has been shown to be a valuable objective tool (Cummins and Platou, 1946;Walker, 1958; Beckman, Gustavson, and Norring, 1965).The ideal of karyotyping all Down's syndrome patients usually is impractical, and karyotyping, even where facilities are available, commonly is restricted to patients of young mothers, those with a familial history of Down's syndrome, or those in whom the clinical picture is atypical.Dermatoglyphic studies from several large European series showed good discrimination be- tween Down's syndrome and control groups (Snedeker, 1948; Penrose, 1949, 1954; Turpin and Lejeune, 1953; Walker, 1957), but only one ethnic investigation on a non-European patient and control series, a Japanese study by Matsui, Nakagome, and Higurashi (1966), appears to have been done.tSuch studies are required since various ethnic groups have different frequency ratios of dermato- glyphic features (Cummins and Midlo, 1943; Tiwari and Chattopadhyay, 1967).The present communication gives a dermatoglyphic analysis of 314 Chinese normal subjects and 53 Chinese patients with the clinical and cytogenetic diagnosis of Down's syndrome.Physical features and the
Source: Journal of Medical Genetics
DOI: 10.1136/jmg.7.4.338
Authors: J I Bryant, I Emanuel, S W Huang, R Kronmal, J Lo
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1971746830