Effect of Polymorphism of the β2-Adrenergic Receptor on Response to Regular Use of Albuterol in Asthma
Year: 2001
Type: article
Abstract: BACKGROUND: Regular use of inhaled beta-adrenergic agonists may have adverse effects in some asthma patients. Polymorphisms of the beta(2)-adrenergic receptor (beta(2)-AR) can affect its regulation; however, results of smaller studies of the effects of such polymorphisms on response to beta-agonist therapy have been inconsistent. METHODS: We examined the possible effects of polymorphisms at codons 16 (beta(2)-AR-16) and 27 (beta(2)-AR-27) on response to albuterol by genotyping 190 asthmatics who had participated in a trial of regular versus as-needed albuterol use. RESULTS: During the 16-week treatment period, patients homozygous for arginine (Arg/Arg) at beta(2)-AR-16 who used albuterol regularly had a small decline in morning peak expiratory flow (AM PEF). This effect was magnified during a 4-week run-out period, when all patients returned to as-needed albuterol only. By the end of the study, Arg/Arg subjects who had used albuterol regularly had an AM PEF 30.5 +/- 12.1 liters/min lower (p = 0.012) than Arg/Arg patients who had used albuterol as needed only. Subjects homozygous for glycine at beta(2)-AR-16 showed no such decline. Evening PEF also declined in the Arg/Arg regular but not in as-need albuterol users. No significant differences between regular and as-needed treatment were associated with polymorphisms at beta(2)-AR-27. CONCLUSIONS: Polymorphisms of the beta(2)-AR may influence airway responses to regular inhaled beta-agonist treatment.
DOI: 10.1159/000053705
Authors: Elliot Israel, Jeffrey M. Drazen, Stephen B. Liggett, Homer A. Boushey, Reuben M. Cherniack, Vernon M. Chinchilli, David M. Cooper, John V. Fahy, James E. Fish, Jean G. Ford, Monica Kraft, Susan Kunselman, Stephen C. Lazarus, Robert F. Lemanske, Jr., Richard J. Martin, Diane E. McLean, Stephen P. Peters, Edwin K. Silverman, Christine A. Sorkness, Stanley J. Szefler, Scott T. Weiss, Chandri N. Yandava
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G13894312, PROGRAMS OF EXCELLENCE IN MOLECULAR BIOLOGY, G1675297940, G2157993154, G2865121620, G367643897, ASTHMA CLINICAL RESEARCH NETWORK, ASTHMA CLINICAL RESEARCH NETWORK (ACRN), G516217854, ASTHMA CLINICAL RESEARCH NETWORK CENTER, G608080541, ASTHMA CLINICAL RESEARCH NETWORK, ASTHMA CLINICAL RESEARCH NETWORK, G66628055, ASTHMA CLINICAL RESEARCH NETWORK, Molecular properties of B-adrenergic receptors in Asthma
OpenAlex ID: W1972228362