Year: 2005
Type: article
Abstract: BACKGROUND: In patients with chronic heart failure, an inadequate increase in muscle blood flow resulting from impaired vasodilation plays a key role in their exercise intolerance. However, no non-invasive methods to assess muscle vasodilation during dynamic exercise were available. We investigated whether the changes in tissue hemoglobin and myoglobin content (total-Hb + Mb) determined by non-invasive measurement using near-infrared spectroscopy (NIRS) reflect vessel conductance of working muscle during exercise. METHODS AND RESULTS: Sixteen patients (10 patients with normal cardiac systolic function, 6 with cardiac dysfunction) performed incremental bicycle exercise testing. Total-Hb + Mb from the right vastus lateralis muscle was monitored using NIRS. Leg blood flow (LBF) in the right femoral vein was measured using a thermodilution technique every 30-60 s. Leg vessel conductance was calculated as LBF/mean arterial pressure at each time of the measurement. In all cases except 1, the levels of total-Hb + Mb showed significant correlation with the leg vessel conductance (r=0.792 to 0.980). Intra-subject reproducibility of the NIRS measurement was also confirmed in 6 patients. CONCLUSIONS: Total-Hb + Mb from NIRS reflected muscle vasodilation during sub-maximal dynamic exercise in patients with and without cardiac dysfunction, indicating that NIRS provides a valuable method to assess the working muscle vasodilation.
Source: Circulation Journal
DOI: 10.1253/circj.69.802
Authors: Shigeyuki Watanabe, Chikako Ishii, Noriyuki Takeyasu, Ryuichi Ajisaka, Hidetaka Nishina, Takafumi Morimoto, Kazuhiko Sakamoto, Kazuhiko Eda, Miki Ishiyama, Takumi Saito, Hideaki Aihara, Emi Arai, Masahiro Toyama, Yoshitaka Shintomi, Iwao Yamaguchi
Institution: University of Tsukuba
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1972981997