Year: 2012
Type: article
Abstract: In this study magnetic fluids were manufactured by the adsorption of chitosan (CS) and O-carboxymethyl chitosan (OCMCS) on Fe 3 O 4 nanoparticles to be used as hyperthermic thermoseeds. Fe 3 O 4 particles were characterized by physico-chemical methods such as: thermogravimetry analysis (TGA), x-ray diffraction (XRD), Raman spectrum, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and vibrating sample magnetometer (VSM). The SEM images and XRD patterns showed that the synthesized Fe 3 O 4 nanoparticles were of single phase and spherical shape with 10–15 nm in diameter. The VSM measurements showed that Fe 3 O 4 particles were superparamagnetic with saturation magnetization of 70 emu g −1. The adsorbed layers of CS and OCMCS on the magnetite surface (Fe 3 O 4/CS) and (Fe 3 O 4/OCMCS) were confirmed by FTIR, Raman spectra and SEM. In the ac magnetic field of 80 Oe and 236 kHz, the saturation heating temperatures of the sample Fe 3 O 4/CS and Fe 3 O 4/OCMCS were 100 and 98 °C, respectively. At the same concentration of Fe 3 O 4 nanoparticles in suspension, the two magnetic fluids exhibited quite high heating capacity, with different behaviors of concentration dependence. The Fe 3 O 4/CS and Fe 3 O 4/OCMCS nanoparticles would serve as good thermoseeds for localized hyperthermia treatment of cancers.
Authors: Thi Thu Trang Mai, Phuong Thu Ha, Hong Nam Pham, Thi Thu Huong Le, Hoai Linh Pham, Thi Bich Hoa Phan, Dai Lam Tran, Xuan Phuc Nguyen
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $1,875
OpenAlex ID: W1978220932