Work

AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS

Year: 1988

Type: article

Abstract: The hst-1 gene, previously designated as the hst gene, and seven other oncogenes were examined for possible structural changes in esophageal, gastric and colorectal carcinomas by Southern blot hybridization. The hst-1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carcinomas and in all four metastatic tumors of lymph nodes. The degree of amplification ranged from two to eight times. Coamplification of the hst-1 and c-erbB-1 gene was found in one case of esophageal carcinoma. However, no amplification of the hst-1 gene was detected in gastric and colorectal carcinomas.

Source: Japanese Journal of Cancer Research

DOI: 10.1111/j.1349-7006.1988.tb00026.x

Authors: Toshitaka Tsuda, Hiroshi Nakatani, Takashi Matsumura, Kazuhiro Yoshida, Eiichi Tahara, Tetsuro Nishihira, Hiromi Sakamoto, Teruhiko Yoshida, Masaaki Terada, Takashi Sugimura

Institutions: Hiroshima University, Tohoku University, National Cancer Center Research Institute

Language: English

Topic: Esophageal Cancer Research and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1978313777

FWCI: 10.25

Cites: 14

Cited by: 41

Related to: 10