Work

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

Year: 1996

Type: article

Abstract: The crystal structures of the catalytic fragment of chicken poly(ADP-ribose) polymerase [NAD+ ADP-ribosyltransferase; NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] with and without a nicotinamide-analogue inhibitor have been elucidated. Because this enzyme is involved in the regulation of DNA repair, its inhibitors are of interest for cancer therapy. The inhibitor shows the nicotinamide site and also suggests the adenosine site. The enzyme is structurally related to bacterial ADP-ribosylating toxins but contains an additional alpha-helical domain that is suggested to relay the activation signal issued on binding to damaged DNA.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.93.15.7481

Authors: A Ruf, J Mennissier de Murcia, G de Murcia, G E Schulz

Institutions: University of Freiburg, Biotechnologie et Signalisation Cellulaire

Language: English

Topic: Enzyme Structure and Function

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W1978367221

FWCI: 9.012

Cites: 29

Cited by: 242

Related to: 10