Work

The Role of Transcription Factors in Cytokine-Mediated Apoptosis of Lymphocytes

Year: 2011

Type: article

Abstract: The role of transcription factors in the implementation of IL-2 and IL-4 proapoptotic effects investigated in the in vitro experiment. It is shown that recombinant IL-2 at a dose of 0.10 ng/ml and IL-4 at a dose of 0.15 ng/ml have apoptotic effects on lymphocytes. At the apoptosis induction by rIL-2 and rIL-4 the transcription factors NF-kB, p53, pRb and inhibitor of cyclin-dependent kinases p21WAF1/CIP1 are activated.

Source: International Journal of Biology

DOI: 10.5539/ijb.v4n1p129

Authors: Olga Evgenevna Saveleva, Larisa Sergeevna Litvinova, Evgeniya Sergeevna Anishchenko, Viacheslav Viktorovish Novitsky, Nataliya Vladimirovna Riazantseva

Institutions: Immanuel Kant Baltic Federal University, Siberian State Medical University

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W1978368221

FWCI:

Cites: 12

Cited by: 2

Related to: 10