Work

C═N-Containing Azaarenes as Activating Groups in Enantioselective Catalysis

Year: 2013

Type: article

Abstract: Nitrogen-containing aromatic heterocycles (azaarenes) are of widespread chemical significance, and chiral compounds containing azaarenes feature prominently in pharmaceuticals, agrochemicals, and natural products. This Perspective highlights the use of a relatively underdeveloped strategy to prepare chiral azaarene-containing compounds: exploitation of the C═N bond embedded within certain azaarenes to activate adjacent functionality in catalytic asymmetric reactions. Work in this area has resulted in the development of several different types of catalytic enantioselective processes, including reductions, nucleophilic additions, and reductive couplings. It is hoped that this Perspective will encourage more researchers to work in this promising area.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo402414k

Authors: Daniel Best, Hon Wai Lam

Institutions: University of Nottingham, University of Edinburgh

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Engineering and Physical Sciences Research Council

Awards: G1080175765, Increasing the Efficiency of Chemical Synthesis Using Asymmetric Transition Metal Catalysis