Work

The Helicobacter pylori CrdRS Two-Component Regulation System (HP1364/HP1365) Is Required for Copper-Mediated Induction of the Copper Resistance Determinant CrdA

Year: 2005

Type: article

Abstract: Here we describe that the Helicobacter pylori sensor kinase produced by HP1364 and the response regulator produced by HP1365 and designated CrdS and CrdR, respectively, are both required for transcriptional induction of the H. pylori copper resistance determinant CrdA by copper ions. CrdRS-deficient mutants lacked copper induction of crdA expression and were copper sensitive. A direct role of CrdR in transcriptional regulation of crdA was confirmed by in vitro binding of CrdR to the crdA upstream region. A 21-nucleotide sequence located near the crdA promoter was shown to be required for CrdR binding.

Source: Journal of Bacteriology

DOI: 10.1128/jb.187.13.4683-4688.2005

Authors: Barbara Waidner, Klaus Melchers, Frank Nils Stähler, Manfred Kist, Stefan Bereswill

Institution: University Medical Center Freiburg

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W1978453574

FWCI: 2.451

Cites: 41

Cited by: 75

Related to: 10