Work

Cyclosporine ophthalmic emulsions for the treatment of dry eye: a review of the clinical evidence

Year: 2015

Type: article

Abstract: Dry eye has gained recognition as a public health problem given its high prevalence, morbidity and cost implications. Although dry eye is common and affects patients' quality of life, only one medication, cyclosporine 0.05% emulsion, has been approved by the US FDA for its treatment. In this review, we summarize the basic science and clinical data regarding the use of cyclosporine in the treatment of dry eye. Randomized controlled trials showed that cyclosporine emulsion outperformed vehicles in the majority of trials, consistently decreasing corneal staining and increasing Schirmer scores. Symptom improvement was more variable, however, with ocular dryness shown to be the most consistently improved symptom over vehicle.

Source: Clinical Investigation

DOI: 10.4155/cli.14.135

Authors: Philip Ames, Anat Galor

Institutions: United States Department of Veterans Affairs, University of Miami, University of Miami Health System, Miami VA Healthcare System

Language: English

Topic: Ocular Surface and Contact Lens

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Eye Institute