OC 08.05: Cardiac function in early childhood in relation to angiogenic factors in cord blood in fetal growth restriction
Year: 2014
Type: conference-abstract
Abstract: To ascertain the relation between an anti-angiogenic status during fetal life and cardiac function and endothelial disease in a cohort of fetal growth restriction (FGR) children at 3–4 years of age. 40 children diagnosed of FGR and followed until 3–5 years of age were included in the study. 25 controls matched for gestational age at delivery were included. At delivery, maternal and perinatal outcome and cord blood samples were obtained. SFlt1 and PlGF were measured in cord blood. At 3–5 years children were evaluated: anthropometric data, metabolic parameters (total cholesterol, LDL, HDL, TG, Apoprotein A1 and B and Lipoprotein A) and cardiac function were evaluated. Mean gestational age at delivery was 32 weeks. In cord blood of FGR fetuses compared to controls, levels of sFlt-1 (580.70 mg/DL vs 207.26 mg/DL) and PlGF levels were lower (7.81 mg/DL vs 20.24 mg/DL). At 3–5 years, these children have subtle systolic and diastolic dysfunction. A correlation was found between sFlt1 levels at birth and left (r=0.7890, p<0.001) and right ventricle (r=0.7505; p<0.001) tissue Doppler Tei Index. No differences were found in metabolic markers at 3–5 years of age. Fetuses with a greater anti-angiogenic status at birth had worse global cardiac function according to higher values of right and left Tei Index. Our data suggest that an imbalance of angiogenic-antiangiogenic factors during intrauterine life might be involved in developmental of cardiovascular dysfunction in human heart.
DOI: 10.1002/uog.13513
Authors: E. Llurba, Q. Ferrer, J. Candel, A. Ruiz, M. Gómez Roig, E. Carreras
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1980560385