Work

In Vivo Antitumor Activity of Novel Water-Soluble Taxoids

Year: 2008

Type: article

Abstract: The antitumor activity of newly developed taxoids possessing a sugar moiety (glucose, galactose or mannose) to improve water solubility was evaluated. Galactose-bound taxoid (10-alpha-GAG-DT) proved superior to all other taxoids in both water solubility and antitumor activity. Therapeutic efficacy of 10-alpha-GAG-DT in terms of in vivo antitumor activity was found to be approximately equivalent to that of docetaxel, which is known to be superior to that of paclitaxel. The observation that the sugar moiety was gradually hydrolyzed in serum to release docetaxel indicates that 10-alpha-GAG-DT acts as a prodrug.

Source: Biological and Pharmaceutical Bulletin

DOI: 10.1248/bpb.31.1155

Authors: Katsuhiko Mikuni, Katsuyoshi Nakanishi, Koji Hara, Kozo Hara, Wakao Iwatani, Tetsuya Amano, Kosho Nakamura, Yoshinori Tsuchiya, Hiroshi Okumoto, Tadakatsu Mandai

Institutions: Ensuiko Sugar Refining (Japan), Kaken Pharmaceutical (Japan), Kurashiki University of Science and the Arts

Language: English

Topic: Cancer Treatment and Pharmacology

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1981019211

FWCI: 0.184

Cites: 16

Cited by: 32

Related to: 10