Year: 1997
Type: article
Abstract: Developmental profiles of antioxidant enzymes and lipid peroxidation were investigated in rat cerebral hemisphere from birth to 600 days of age. Lipid peroxidation level decreased in the crude homogenate from birth until 15 days and, thereafter increased gradually up to 600 days. However, susceptibility of sub-cellular fractions to lipid peroxidation displayed an increasing trend with increasing age. Superoxide dismutase activity decreased gradually with age, whereas activities of catalase, glutathione peroxidase and glutathione reductase exhibited an elevation up to 90 days followed by either a stagnancy or diminution in the later life. No linearity was observed in the contents of glutathione, ascorbic acid and H2O2 in the tissue. The results suggest that free radicals could be the causative agents of the aging process in which antioxidant enzymes have a definite regulatory contribution.
Authors: Arjun Sahoo, G.B.N. Chainy
Language: English
Subfield: Biochemistry (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: University Grants Commission
OpenAlex ID: W1981124126