Year: 2014
Type: review
Abstract: The hair bundles of cochlear hair cells play a central role in the auditory mechano-electrical transduction (MET) process. The identification of MET components and of associated molecular complexes by biochemical approaches is impeded by the very small number of hair cells within the cochlea. In contrast, human and mouse genetics have proven to be particularly powerful. The study of inherited forms of deafness led to the discovery of several essential proteins of the MET machinery, which are currently used as entry points to decipher the associated molecular networks. Notably, MET relies not only on the MET machinery but also on several elements ensuring the proper sound-induced oscillation of the hair bundle or the ionic environment necessary to drive the MET current. Here, we review the most significant advances in the molecular bases of the MET process that emerged from the genetics of hearing.
Authors: Nicolas Michalski, Christine Petit
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
Awards: Assembling the puzzle of the operating auditory hair bundle, G2647246237, G4031799020, G4866930200, G5551520971, G5615659713, G5665028823, Sorbonne Universités à Paris pour l'Enseignement et la Recherche, G7240651115, G7376787254, Active and passive mechanics of the mechanosensory hair-cell bundle along the tonotopic axis of the mammalian cochlea.
OpenAlex ID: W1982452191