Year: 1955
Type: article
Abstract: S ol the posterior lobe or stalk of the T pituitary gland are rare.In 1893, Boyce and Beadles described a small tumor, a fourth of an inch in diameter, arising in the infundibulum of the pituitary gland.This tumor, an incidental finding at necropsy in a patient who had had senile dementia, was composed of large pale cells, often without nuclei, that were arranged in irregular cords.Sternberg, in 1921, described a small nodule of large granular cells in the posterior lobe of the hypophysis.This nodule he termed a "choristoma" and believed it to be of glial origin.Priesel, in 1922, reported small aggregates of abnormal large granular cells in the neurohypophysis in twenty additional cases.All of these nodules were found incidentally at necropsy and, for the most part, occurred among elderly individuals.I n 1925 Siinonds and Brandes described similar groups of cells i n the neurohypophysis in eight patients.They considered these nodules to be of glial origin and the result of a local retrogressive change, the cause of which was not apparent, rather than a neoplaslic change.In 1926 Kiyono and Kraus discussed aggregates of granular cells in the posterior lobe and stalk of the pituitary gland that they thought were of glial origin.Lamer, in 1929, reported several cases in which nodules of granular cells in the neurohypophysis were incidental findings at necropsy.His theory of origin of these tumors is discussed by Shank-In 1932 Bailey pointed out the rarity of tumors of the neural portion of the pituitary gland and mentioned the microscopic tumors, choristomas, described by Sternberg.Roussy and Oberling described a similar small tumor in 1933, and in 1940 Romeis described another.N o further mention was made 01 these small tumors until 1947 when Shanklin21 examined eighty-two human pituitary glands by serial sections.In 1953 Shanklin22 reported on serial sections of 100 human pituitary glands in 17 per cent of which he observed "tumor-From the Section of Pathologic Anatomy, the Mayo Clinic, and the Mayo Foundation, Rochester, Minne sota.
Source: Cancer
Authors: Sarah A. Luse, James W. Kernohan
Institution: Mayo Clinic
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1982918891