Work

Alkynes as Equivalents of α-Diazo Ketones in Generating α-Oxo Metal Carbenes: A Gold-Catalyzed Expedient Synthesis of Dihydrofuran-3-ones

Year: 2010

Type: article

Abstract: An expedient and reliable method for accessing reactive alpha-oxo gold carbenes via gold-catalyzed intermolecular oxidation of terminal alkynes has been developed. Significantly, this method offers a safe and economical alternative to the strategies based on diazo substrates. Its synthetic potential is demonstrated by expedient preparation of dihydrofuran-3-ones containing a broad range of functional groups.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja100041e

Authors: Longwu Ye, Li Cui, Guozhu Zhang, Liming Zhang

Institution: University of California, Santa Barbara

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Au/Pt Catalysis in the Synthesis of Elaborate N-Heterocycles: Methodology Develop