Metabolic Connectivity as Index of Verbal Working Memory
Year: 2015
Type: article
Study design: Observational Study
Abstract: Positron emission tomography (PET) data are commonly analyzed in terms of regional intensity, while covariant information is not taken into account. Here, we searched for network correlates of healthy cognitive function in resting state PET data. PET with [(18)F]-fluorodeoxyglucose and a test of verbal working memory (WM) were administered to 35 young healthy adults. Metabolic connectivity was modeled at a group level using sparse inverse covariance estimation. Among 13 WM-relevant Brodmann areas (BAs), 6 appeared to be robustly connected. Connectivity within this network was significantly stronger in subjects with above-median WM performance. In respect to regional intensity, i.e., metabolism, no difference between groups was found. The results encourage examination of covariant patterns in FDG-PET data from non-neurodegenerative populations.
Institutions: Arizona State University, Inserm, École Pratique des Hautes Études, Université de Caen Normandie, Boğaziçi University, University Medical Center of the Johannes Gutenberg University Mainz, TUM Klinikum, Technical University of Munich, Centre Hospitalier Universitaire Vaudois, Max Planck Institute for Human Cognitive and Brain Sciences
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1982945123