Work

Prevention by an inhibitor of the l ‐arginine‐nitric oxide pathway of the antiarrhythmic effects of bradykinin in anaesthetized dogs

Year: 1993

Type: article

Abstract: The intracoronary administration of bradykinin (25 ng kg-1 min-1) markedly reduces the severity of arrhythmias that occur during a 25 min occlusion of the left anterior descending coronary artery in chloralose, urethane anaesthetized dogs. This protection was abolished by the prior administration, by the same route, of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of the L-arginine-nitric oxide pathway. The protective effect of bradykinin on reperfusion-induced VF was not affected by L-NAME. These results strongly suggest that the antiarrhythmic effect of bradykinin in this model is mediated by nitric oxide release. It also supports the concept that bradykinin might be a 'primary mediator' of the protective, antiarrhythmic effects of ischemic preconditioning.

Source: British Journal of Pharmacology

DOI: 10.1111/j.1476-5381.1993.tb13764.x

Authors: Agnes Vegh, Julius Gy Papp, Laszlo Szekeres, James R. Parratt

Institutions: University of Szeged, University of Strathclyde

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Wellcome Trust