Work

Effect of loperamide and naloxone on mouth-to-caecum transit time evaluated by lactulose hydrogen breath test.

Year: 1985

Type: article

Abstract: The effect of loperamide and naloxone on mouth-to-caecum transit time was evaluated by the lactulose hydrogen breath test in four men and four women. Each subject underwent tests during the administration of placebo, loperamide (12-16 mg po), naloxone (40 micrograms/kg/h by a three-hour intravenous infusion), and loperamide plus naloxone, carried out at intervals of one or two weeks. The transit time was significantly longer after loperamide, and this effect was antagonised by the concomitant administration of naloxone whereas naloxone administered alone had no effect on mean transit time. No clinically important side effects were reported.

Source: Gut

DOI: 10.1136/gut.26.7.700

Authors: G Basilisco, A Bozzani, G Camboni, M Recchia, M Quatrini, D Conte, R Penagini, P A Bianchi

Institutions: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Mario Negri Institute for Pharmacological Research

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1983555005

FWCI: 3.103

Cites: 21

Cited by: 56

Related to: 10