Work

HPLC-Assisted Automated Oligosaccharide Synthesis

Year: 2012

Type: article

Abstract: A standard HPLC was adapted to polymer supported oligosaccharide synthesis. Solution-based reagents are delivered using a software-controlled solvent delivery system. The reaction progress and completion can be monitored in real time using a standard UV detector. All steps of oligosaccharide assembly including loading, glycosylation, deprotection, and cleavage can be performed using this setup.

Source: Organic Letters

DOI: 10.1021/ol301105y

Authors: N. Vijaya Ganesh, Kohki Fujikawa, Yih Horng Tan, Keith J. Stine, Alexei V. Demchenko

Institution: University of Missouri–St. Louis

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: New strategies for expeditious oligosaccharide synthesis, Development and Application of Surface-Tethered Iterative Carbohydrate Synthesis