Year: 2012
Type: article
Abstract: Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus complete genomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3' noncoding region (3'NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findings suggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.
Source: Journal of Virology
DOI: 10.1128/jvi.00565-12
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Award: Northeast Biodefense Center
OpenAlex ID: W1984245367