Work

PPARγ mediates NSAIDs‐induced upregulation of TFF2 expression in gastric epithelial cells

Year: 2004

Type: article

Abstract: Trefoil factor family (TFF) is a group of peptides that play critical roles in maintaining gastric mucosal integrity. In real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) and reporter gene assays, we show that indomethacin and aspirin upregulate TFF2 expression in MKN45 gastric cells. These drugs also activated peroxisome proliferator-activated receptor gamma (PPARgamma) at concentration ranges that increase TFF2 expression, and upregulated TFF2 expression was suppressed by GW9662, a specific inhibitor of PPARgamma. These results suggest that indomethacin and aspirin upregulate gastric expression of TFF2 through activation of PPARgamma. This mechanism may be important in reducing the extent of gastric mucosal injury caused by the administration of non-steroidal anti-inflammatory drugs (NSAIDs).

Source: FEBS Letters

DOI: 10.1016/s0014-5793(03)01527-8

Authors: Tadahito Shimada, Ayako Koitabashi, Yoichiro Fujii, Takashi Hashimoto, Kumi Hosaka, Kyoko Tabei, Takashi Namatame, Masashi Yoneda, Hideyuki Hiraishi, Akira Terano

Institutions: Dokkyo University, Dokkyo Medical University

Language: English

Topic: Peroxisome Proliferator-Activated Receptors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1985149017

FWCI: 0.683

Cites: 30

Cited by: 22

Related to: 10