Work

Effect of Harmane on Mononeuropathic Pain in Rats

Year: 2003

Type: article

Abstract: This study was designed to investigate the effect of the endogenous beta-carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti-allodynic effect in a dose-dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain.

Source: Annals of the New York Academy of Sciences

DOI: 10.1196/annals.1304.021

Authors: FEYZA ARICIOGLU, EYLEM KORCEGEZ, SULEYMAN OZYALCIN

Institutions: Marmara University, Istanbul University

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1985193347

FWCI: 0.182

Cites: 12

Cited by: 10

Related to: 10