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Influence of Some Anti-inflammatory, Antipyretic and Analgesic Agents on Urinary Enzyme Level in Rats

Year: 1978

Type: article

Abstract: The influence of single oral dose of anti-inflammatory, antipyretic and analgesic agents on urinary enzymes was investigated in rats as a indicator of nephrotoxic effect. Urinary LDH activity was significantly elevated by aspirin, ketophenylbutazone, aminopyrine, phenacetin and acetaminophen. These drugs increased also H/M ratio of LDH isoenzymes. Although other test drugs have no effect on LDH in urine phenylbutazone and indomethacin elevated GPT and A1-P, oxyphenbutazone did gamma-GT and anthranilic acid derivatives did Al-P and gamma-GT. Other drugs such as sodium salicylate, ibufenac, ibuprofen, bucolome, aminopropylone, sulfinpyrazone, benzydamine and mepirizole did not significantly influence any enzyme activities measured in urine.

Source: The Journal of Toxicological Sciences

DOI: 10.2131/jts.3.1

Authors: Kaito TSURUMI, Akira ABE, Masakatsu NOZAKI, Hajime FUJIMURA

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1985261031

FWCI: 0.49

Cites: 20

Cited by: 7

Related to: 10