Work

Estrogenic Activities of Chemicals in Diesel Exhaust Particles.

Year: 2002

Type: article

Abstract: In a previous study, we focused on estrogenic activity of the hexane extract of diesel exhaust particles (DEP). The extract of hexane was first fractionated to acidic, phenolic and neutral portions according to their chemical properties, of which the neutral fraction was fractionated by column chromatography on silica gel. The chemical structures of compounds in these fractions were then analyzed. It was found that the neutral fraction of the hexane extract of DEP contains dibenzothiophene derivatives, one of which, 4,6-dimethyldibenzothiophene, possesses estrogenic activity.

Source: Biological and Pharmaceutical Bulletin

DOI: 10.1248/bpb.25.145

Authors: Yoki Mori, Shinji Taneda, Hideyuki Hayashi, Akiyo Sakushima, Kazuyuki Kamata, Akira K. Suzuki, Shin Yoshino, Masakatsu Sakata, Masaru Sagai, Koh-ichi Seki

Institutions: Health Sciences University of Hokkaido, National Institute for Environmental Studies, Kobe Pharmaceutical University, Aomori University of Health and Welfare

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

Open Access status: bronze

Funder: Ministry of Education, Culture, Sports, Science and Technology

OpenAlex ID: W1985653999

FWCI: 1.674

Cites: 13

Cited by: 31

Related to: 10