Work

Regiocontrolled Ring Opening of Monoprotected 2,3-Epoxy-1,4-diols by Using Alkynyl Aluminum Reagents: Synthesis of Differentially Monoprotected Alkynyl Triol Derivatives

Year: 2013

Type: article

Abstract: The regioselectivity of the epoxide ring opening reaction of cis and trans TIPS-monoprotected 2,3-epoxy-1,4-diols with diethylalkynyl aluminum reagents was studied. Alane and alanate conditions in toluene or dichloromethane were explored. The alkynyl attack at the C2 epoxide carbon was favored for both, the alane and alanate conditions in toluene, while in dichloromethane the C3 attack was preferred. The best regioselectivities were obtained using the alanate conditions in toluene. This methodology provides access to differentially monoprotected alkynyl triols with high diastereoselectivity. These compounds are useful building bocks for polypropionate synthesis and are precursors for the introduction of the hydroxymethyl moiety found in some polyketide systems.

Source: Synlett

DOI: 10.1055/s-0033-1340332

Authors: José Prieto, Jaileen Torres, Raul Rodríguez-Berrios

Institution: University of Puerto Rico System

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: Syntesis of Polypropionate Antibiotics Via Epoxide Chemistry, Support for University Biomedical Excellence at UPR-RP