Work

Sit down, relax and unwind: structural insights into RecQ helicase mechanisms

Year: 2006

Type: review

Abstract: Helicases are specialized molecular motors that separate duplex nucleic acids into single strands. The RecQ family of helicases functions at the interface of DNA replication, recombination and repair in bacterial and eukaryotic cells. They are key, multifunctional enzymes that have been linked to three human diseases: Bloom's, Werner's and Rothmund-Thomson's syndromes. This review summarizes recent studies that relate the structures of RecQ proteins to their biochemical activities.

Source: Nucleic Acids Research

DOI: 10.1093/nar/gkl538

Authors: Michael P. Killoran, James L. Keck

Institutions: University of Wisconsin System, University of Wisconsin–Madison

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,992

Funders: National Institutes of Health, U.S. Bureau of Land Management, National Institute of General Medical Sciences