Work

Metal-enhanced chemiluminescence: advanced chemiluminescence concepts for the 21st century

Year: 2009

Type: review

Abstract: Chemiluminescent-based detection is entrenched throughout the biosciences today, such as in blotting, analyte and protein quantification and detection. While the biological applications of chemiluminescence are forever growing, the underlying principles of using a probe, an oxidizer and a catalyst (biological, organic or inorganic) have remained mostly unchanged for decades. Subsequently, chemiluminescence-based detection is fundamentally limited by the classical photochemical properties of reaction yield, quantum yield, etc. However, over the last 5 years, a new technology has emerged which looks set to fundamentally change the way we both think about and use chemiluminescence today. Metal surface plasmons can amplify chemiluminescence signatures, while low-power microwaves can complete reactions within seconds. In addition, thin metal films can convert spatially isotopic chemiluminescence into directional emission. In this forward looking tutorial review, we survey what could well be the next-generation chemiluminescent-based technologies.

Source: Chemical Society Reviews

DOI: 10.1039/b807498b

Authors: Kadir Aslan, Chris D. Geddes

Institutions: University of Maryland, Baltimore, University of Maryland Biotechnology Institute

Language: English

Topic: bioluminescence and chemiluminescence research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering

Awards: Ultra Fast and Sensitive Fluorescence-Based Clinical Assays, Middle Atlantic Regional Center for Excellence for Biodefense and Emerging Infect, Plasmonic Detection of Free-Bilirubin in Neonates, G897121438, G9000018249