Work

Mechanical post-conditioning in STEMI patients undergoing primary percutaneous coronary intervention

Year: 2014

Type: review

Abstract: Although early myocardial reperfusion via primary percutaneous coronary intervention (PCI) allows the preservation of left ventricular function and improves outcome, the acute restoration of blood flow may contribute to the pathophysiology of infarction, a complex phenomenon called reperfusion injury. First described in animal models of coronary obstruction, mechanical post-conditioning, a sequence of repetitive interruption of coronary blood flow applied immediately after reopening of the occluded vessel, was able to reduce the infarct size. However, evidence of its real benefit remains controversial. This review describes the mechanisms of post-conditioning action and the different protocols employed focusing on its impact on primary PCI outcome.

Source: Journal of the Saudi Heart Association

DOI: 10.1016/j.jsha.2014.11.001

Authors: Marouane Boukhris, Radhouane Bousselmi, Salvatore Davide Tomasello, Zied Ibn Elhadj, Salvatore Azzarelli, Francesco Marzà, Alfredo R. Galassi

Institutions: Tunis University, University of Catania, Ospedale Cannizzaro, Faculté de médecine de Tunis, Tunis El Manar University

Language: English

Topic: Cardiac Ischemia and Reperfusion

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1987273147

FWCI:

Cites: 53

Cited by: 4

Related to: 10