Work

Endogenous Ligands for Nuclear Receptors: Digging Deeper

Year: 2010

Type: article

Abstract: Nuclear receptors (NRs) are hormone-sensing transcription factors that translate dietary or endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs through the identification of their endogenous ligands is a key element for our understanding of their biology. In this minireview, we give an update on recent progress in regard to endogenous ligands for a cluster of NRs with high sequence homology, namely peroxisome proliferator-activated receptors α and γ, Rev-erbα, and related receptors. This knowledge about the nature and physiology of these ligands may create new opportunities for therapeutic drug development.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r110.182451

Authors: Michael Schupp, Mitchell A. Lazar

Institutions: Charité - Universitätsmedizin Berlin, University of Pennsylvania Health System, University of Pennsylvania

Language: English

Topic: Peroxisome Proliferator-Activated Receptors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430