Work

Proteomic identification of activin receptor‐like kinase‐1 as a differentially expressed protein during hyaloid vascular system regression

Year: 2005

Type: article

Abstract: The hyaloid vascular system (HVS) is a transient network of capillaries that nourishes the embryonic lens and the primary vitreous of the developing eye. We used proteomic analysis and immunohistochemical staining to identify activin receptor-like kinase-1 (ALK1), a type I receptor for transforming growth factor-beta1, during the HVS regression phase. In addition, we overexpressed ALK1 in corneas implanted with bFGF (basic fibroblast growth factor) pellets and observed that ALK1 overexpression resulted in inhibition of bFGF-induced corneal neovascularization in vivo. Our data suggest that ALK1 may play a role in HVS regression during ocular development.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2005.08.078

Authors: Elena Albè, Elizabeth Escalona, Rama Rajagopal, Joel A. Javier, Jin-Hong Chang, Dimitri T. Azar

Institutions: Massachusetts Eye and Ear Infirmary, Harvard University

Language: English

Topic: Ocular Disorders and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,980