Work

Preliminary Evaluation of Antimicrobial Activity of Diastereomeric cis/trans-3-Aryl(Heteroaryl)-3,4-dihydroisocoumarin-4-carboxylic Acids

Year: 2007

Type: article

Abstract: Preliminary differentiating screening of the antibacterial and antifungal activity of a series of diastereomeric cis/trans-3-aryl(heteroaryl)-3,4-dihydroisocoumarin-4-carboxylic acids (3a-i) was performed by the agar diffusion method against twelve microorganism strains of different taxonomic groups. S. aureus and A. niger were the most sensitive strains to the antibiotic effect of the tested compounds, both inhibited by 10 of 12 compounds. The most potent antibacterial agent was cis-3-phenyl-3,4-dihydroisocoumarin-4-carboxylic acid (cis-3a), exhibiting activity against all seven bacterial test strains.

Source: Zeitschrift für Naturforschung C

DOI: 10.1515/znc-2007-7-804

Authors: Milen G. Bogdanov, Meglena I. Kandinska, Darina B. Dimitrova, Blagovesta T. Gocheva, Mariana D. Palamareva

Institution: Sofia University "St. Kliment Ohridski"

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,712