Studies on the Metabolic Fate and the Pharmacokinetics of 5-n-Butyl-1-cyclohexy1-2, 4, 6-trioxoperhydropyrimidine (BCP) in Man. V. Pharmacokinetics of BCP in Man and in Rabbit following Intravenous Administration of BCPNa
Year: 1971
Type: article
Abstract: In order to support the application of the model 1 to simulate the behavior of 5-nbutyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP) in man, further studies were carried out independently in man and in rabbits.The human plasma concentration and urinary excretion after the intravenous administration of BCPNa in a clinical test were simulated well by the model 1 with the same order of values for the rate constants as in the oral administration.Then, using rabbits, BCP in organs and tissues along with the plasma concentration and urinary excretion were determined and compared with the simulated values by the model 1.After correction for the mass balance, the tissue amounts of BCP were simulated fairly well.These results indicated the applicability of the model 1 both in man and in rabbits.
DOI: 10.1248/cpb.19.881
Institutions: Takeda (Japan), Kansai Medical University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1992011016