Work

Calcium‐associated mechanisms in gut pacemaker activity

Year: 2007

Type: review

Abstract: A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca(2+) activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca(2+) oscillations in ICC periodically activate plasmalemmal Ca(2+)-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca(2+)-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.

Source: Journal of Cellular and Molecular Medicine

DOI: 10.1111/j.1582-4934.2007.00107.x

Authors: Shinsuke Nakayama, Shunichi Kajioka, Kazunori Goto, Miyako Takaki, Hong‐Nian Liu

Institutions: Nagoya University, University of Oxford, Kyoto University, Nara Medical University

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,210